diff --git a/scripts/setup/generate_secrets.py b/scripts/setup/generate_secrets.py
index cc1d0ba7b6..3dfb6f0cec 100755
--- a/scripts/setup/generate_secrets.py
+++ b/scripts/setup/generate_secrets.py
@@ -61,7 +61,7 @@ def get_old_conf(output_filename):
     secrets_file = six.moves.configparser.RawConfigParser()
     secrets_file.read(output_filename)
 
-    return dict(secrets_file.items("secrets"))  # type: ignore # likely typeshed issue
+    return dict(secrets_file.items("secrets"))
 
 def generate_secrets(development=False):
     # type: (bool) -> None
diff --git a/tools/show-profile-results.py b/tools/show-profile-results.py
index 9a9be06bce..39c9b5574d 100755
--- a/tools/show-profile-results.py
+++ b/tools/show-profile-results.py
@@ -19,6 +19,6 @@ except IndexError:
     ''')
     sys.exit(1)
 
-p = pstats.Stats(fn)  # type: ignore # stats stubs are broken
+p = pstats.Stats(fn)
 p.strip_dirs().sort_stats('cumulative').print_stats(25)  # type: ignore # stats stubs are broken
 p.strip_dirs().sort_stats('time').print_stats(25)  # type: ignore # stats stubs are broken
diff --git a/tools/test-backend b/tools/test-backend
index ef49ec2a85..ee9a777b7a 100755
--- a/tools/test-backend
+++ b/tools/test-backend
@@ -150,7 +150,7 @@ def block_internet():
                         "https://zulip.readthedocs.io/en/latest/testing.html#internet-access-inside-test-suits")
 
     httplib2.Http.request = internet_guard
-    requests.request = internet_guard  # type: ignore # mypy bug; see our #6017
+    requests.request = internet_guard
 
 if __name__ == "__main__":
     block_internet()
diff --git a/tools/test-tools b/tools/test-tools
index 92f9e441ce..542576c662 100755
--- a/tools/test-tools
+++ b/tools/test-tools
@@ -38,7 +38,7 @@ if __name__ == '__main__':
 
     suite = loader.discover(start_dir=tools_test_dir, top_level_dir=root_dir)
     runner = unittest.TextTestRunner(verbosity=2)
-    result = runner.run(suite)  # type: ignore # https://github.com/python/typeshed/issues/372
+    result = runner.run(suite)
     if result.errors or result.failures:
         raise Exception('Test failed!')
 
diff --git a/tools/tests/test_css_parser.py b/tools/tests/test_css_parser.py
index b29ebdca42..852168393a 100644
--- a/tools/tests/test_css_parser.py
+++ b/tools/tests/test_css_parser.py
@@ -19,14 +19,6 @@ except ImportError:
     sys.exit(1)
 
 class ParserTestHappyPath(unittest.TestCase):
-    def __init__(self, *args, **kwargs):
-        # type: (*Any, **Any) -> None
-        # This method should be removed when we migrate to version 3 of Python
-        import six
-        if six.PY2:
-            self.assertRaisesRegex = self.assertRaisesRegexp  # type: ignore
-        super(ParserTestHappyPath, self).__init__(*args, **kwargs)
-
     def test_basic_parse(self):
         # type: () -> None
         my_selector = 'li.foo'
@@ -170,14 +162,6 @@ class ParserTestSadPath(unittest.TestCase):
     of selectors.  Some of this is just for expediency;
     some of this is to enforce consistent formatting.
     '''
-    def __init__(self, *args, **kwargs):
-        # type: (*Any, **Any) -> None
-        # This method should be removed when we migrate to version 3 of Python
-        import six
-        if six.PY2:
-            self.assertRaisesRegex = self.assertRaisesRegexp  # type: ignore
-        super(ParserTestSadPath, self).__init__(*args, **kwargs)
-
     def _assert_error(self, my_css, error):
         # type: (str, str) -> None
         with self.assertRaisesRegex(CssParserException, error):
diff --git a/tools/tests/test_template_parser.py b/tools/tests/test_template_parser.py
index 10a5b6dc5b..b67d566285 100644
--- a/tools/tests/test_template_parser.py
+++ b/tools/tests/test_template_parser.py
@@ -18,14 +18,6 @@ except ImportError:
     sys.exit(1)
 
 class ParserTest(unittest.TestCase):
-    def __init__(self, *args, **kwargs):
-        # type: (*Any, **Any) -> None
-        # This method should be removed when we migrate to version 3 of Python
-        import six
-        if six.PY2:
-            self.assertRaisesRegex = self.assertRaisesRegexp  # type: ignore
-        super(ParserTest, self).__init__(*args, **kwargs)
-
     def _assert_validate_error(self, error, fn=None, text=None, check_indent=True):
         # type: (str, Optional[str], Optional[str], bool) -> None
         with self.assertRaisesRegex(TemplateParserException, error):
diff --git a/zerver/lib/cache.py b/zerver/lib/cache.py
index 4e57beefd6..90ef6ebe84 100644
--- a/zerver/lib/cache.py
+++ b/zerver/lib/cache.py
@@ -287,7 +287,7 @@ def cache(func):
        Uses a key based on the function's name, filename, and
        the repr() of its arguments."""
 
-    func_uniqifier = '%s-%s' % (func.__code__.co_filename, func.__name__)  # type: ignore # https://github.com/python/mypy/issues/1923
+    func_uniqifier = '%s-%s' % (func.__code__.co_filename, func.__name__)
 
     @wraps(func)
     def keyfunc(*args, **kwargs):
diff --git a/zerver/lib/exceptions.py b/zerver/lib/exceptions.py
index ceb1ca4d6f..e28c5e420c 100644
--- a/zerver/lib/exceptions.py
+++ b/zerver/lib/exceptions.py
@@ -10,7 +10,7 @@ class AbstractEnum(Enum):
     def __new__(cls):
         # type: (Type[AbstractEnum]) -> AbstractEnum
         obj = object.__new__(cls)
-        obj._value_ = len(cls.__members__) + 1  # type: ignore # typeshed enum missing Enum.__members__
+        obj._value_ = len(cls.__members__) + 1
         return obj
 
     # Override all the `Enum` methods that use `_value_`.
@@ -144,7 +144,7 @@ class JsonableError(Exception):
 
     def __str__(self):
         # type: () -> str
-        return self.msg  # type: ignore # remove once py3-only
+        return self.msg
 
 class RateLimited(PermissionDenied):
     def __init__(self, msg=""):
diff --git a/zerver/lib/test_helpers.py b/zerver/lib/test_helpers.py
index 2434c3d37a..184fbc0b49 100644
--- a/zerver/lib/test_helpers.py
+++ b/zerver/lib/test_helpers.py
@@ -180,7 +180,7 @@ def stdout_suppressed():
     """Redirect stdout to /dev/null."""
 
     with open(os.devnull, 'a') as devnull:
-        stdout, sys.stdout = sys.stdout, devnull  # type: ignore # monkey-patching
+        stdout, sys.stdout = sys.stdout, devnull
         yield stdout
         sys.stdout = stdout
 
diff --git a/zerver/lib/test_runner.py b/zerver/lib/test_runner.py
index edbf718dac..3365991084 100644
--- a/zerver/lib/test_runner.py
+++ b/zerver/lib/test_runner.py
@@ -256,7 +256,7 @@ def run_subsuite(args):
     # type of Partial is different from Callable. All the methods of
     # TestResult are passed TestCase as the first argument but
     # addInstrumentation does not need it.
-    process_instrumented_calls(partial(result.addInstrumentation, None))  # type: ignore
+    process_instrumented_calls(partial(result.addInstrumentation, None))
     return subsuite_index, result.events
 
 # Monkey-patch database creation to fix unnecessary sleep(1)
@@ -365,7 +365,7 @@ class TestSuite(unittest.TestSuite):
         if getattr(result, '_testRunEntered', False) is False:
             result._testRunEntered = topLevel = True
 
-        for test in self:  # type: ignore  # Mypy cannot recognize this
+        for test in self:
             # but this is correct. Taken from unittest.
             if result.shouldStop:
                 break
@@ -503,7 +503,7 @@ def get_test_names(suite):
 
 def get_tests_from_suite(suite):
     # type: (TestSuite) -> TestCase
-    for test in suite:  # type: ignore
+    for test in suite:
         if isinstance(test, TestSuite):
             for child in get_tests_from_suite(test):
                 yield child
diff --git a/zerver/storage.py b/zerver/storage.py
index de4b5b638e..bc546b1011 100644
--- a/zerver/storage.py
+++ b/zerver/storage.py
@@ -43,7 +43,7 @@ class AddHeaderMixin(object):
 
             ret_dict[path] = (path, path, True)
 
-        super_class = super(AddHeaderMixin, self)  # type: ignore # https://github.com/JukkaL/mypy/issues/857
+        super_class = super(AddHeaderMixin, self)
         if hasattr(super_class, 'post_process'):
             super_ret = super_class.post_process(paths, dry_run, **kwargs)  # type: ignore # https://github.com/python/mypy/issues/2956
         else:
@@ -73,7 +73,7 @@ class RemoveUnminifiedFilesMixin(object):
         is_valid = lambda p: all([not p.startswith(k) for k in to_remove])
 
         paths = {k: v for k, v in paths.items() if is_valid(k)}
-        super_class = super(RemoveUnminifiedFilesMixin, self)  # type: ignore # https://github.com/JukkaL/mypy/issues/857
+        super_class = super(RemoveUnminifiedFilesMixin, self)
         if hasattr(super_class, 'post_process'):
             return super_class.post_process(paths, dry_run, **kwargs)  # type: ignore # https://github.com/python/mypy/issues/2956
 
diff --git a/zerver/tests/test_narrow.py b/zerver/tests/test_narrow.py
index 7c17f127a4..a1a75d4c8a 100644
--- a/zerver/tests/test_narrow.py
+++ b/zerver/tests/test_narrow.py
@@ -8,7 +8,7 @@ from django.test import override_settings
 from sqlalchemy.sql import (
     and_, select, column, table,
 )
-from sqlalchemy.sql import compiler  # type: ignore
+from sqlalchemy.sql import compiler
 
 from zerver.models import (
     Realm, Recipient, Stream, Subscription, UserProfile, Attachment,
@@ -50,7 +50,7 @@ import ujson
 
 def get_sqlalchemy_query_params(query):
     # type: (Text) -> Dict[Text, Text]
-    dialect = get_sqlalchemy_connection().dialect  # type: ignore
+    dialect = get_sqlalchemy_connection().dialect
     comp = compiler.SQLCompiler(dialect, query)
     return comp.params
 
diff --git a/zerver/tests/test_push_notifications.py b/zerver/tests/test_push_notifications.py
index cb94d88224..5ae6c27cb0 100644
--- a/zerver/tests/test_push_notifications.py
+++ b/zerver/tests/test_push_notifications.py
@@ -256,7 +256,7 @@ class PushNotificationTest(BouncerTestCase):
         super(PushNotificationTest, self).setUp()
         self.user_profile = self.example_user('hamlet')
         apn.connection = apn.get_connection('fake-cert', 'fake-key')
-        self.redis_client = apn.redis_client = MockRedis()  # type: ignore
+        self.redis_client = apn.redis_client = MockRedis()
         self.tokens = [u'aaaa', u'bbbb']
         for token in self.tokens:
             PushDeviceToken.objects.create(
diff --git a/zerver/tests/test_type_debug.py b/zerver/tests/test_type_debug.py
index 412ea411db..aaa251bf0a 100644
--- a/zerver/tests/test_type_debug.py
+++ b/zerver/tests/test_type_debug.py
@@ -49,7 +49,7 @@ class TypesPrintTest(TestCase):
         def empty_func():
             # type: () -> None
             pass
-        self.check_signature("empty_func() -> None", None, empty_func)  # type: ignore # https://github.com/python/mypy/issues/1932
+        self.check_signature("empty_func() -> None", None, empty_func)
         self.check_signature("<lambda>() -> None", None, (lambda: None))  # type: ignore # https://github.com/python/mypy/issues/1932
 
     def test_basic(self):
diff --git a/zerver/tornado/application.py b/zerver/tornado/application.py
index b38281e7b2..a3ece857bf 100644
--- a/zerver/tornado/application.py
+++ b/zerver/tornado/application.py
@@ -18,7 +18,7 @@ def setup_tornado_rabbitmq():
     if settings.USING_RABBITMQ:
         queue_client = get_queue_client()
         atexit.register(lambda: queue_client.close())
-        tornado.autoreload.add_reload_hook(lambda: queue_client.close())  # type: ignore # TODO: Fix missing tornado.autoreload stub
+        tornado.autoreload.add_reload_hook(lambda: queue_client.close())
 
 def create_tornado_application():
     # type: () -> tornado.web.Application
diff --git a/zerver/tornado/event_queue.py b/zerver/tornado/event_queue.py
index be3c686324..7c80d98e95 100644
--- a/zerver/tornado/event_queue.py
+++ b/zerver/tornado/event_queue.py
@@ -473,7 +473,7 @@ def setup_event_queue():
         atexit.register(dump_event_queues)
         # Make sure we dump event queues even if we exit via signal
         signal.signal(signal.SIGTERM, lambda signum, stack: sys.exit(1))
-        tornado.autoreload.add_reload_hook(dump_event_queues)  # type: ignore # TODO: Fix missing tornado.autoreload stub
+        tornado.autoreload.add_reload_hook(dump_event_queues)
 
     try:
         os.rename(settings.JSON_PERSISTENT_QUEUE_FILENAME, "/var/tmp/event_queues.json.last")
diff --git a/zerver/tornado/ioloop_logging.py b/zerver/tornado/ioloop_logging.py
index c081d22478..bec7b29732 100644
--- a/zerver/tornado/ioloop_logging.py
+++ b/zerver/tornado/ioloop_logging.py
@@ -8,28 +8,19 @@ import select
 from tornado import ioloop
 from django.conf import settings
 
-try:
-    # Tornado 2.4
-    orig_poll_impl = ioloop._poll  # type: ignore # cross-version type variation is hard for mypy
+from tornado.ioloop import IOLoop, PollIOLoop
+# There isn't a good way to get at what the underlying poll implementation
+# will be without actually constructing an IOLoop, so we just assume it will
+# be epoll.
+orig_poll_impl = select.epoll
 
-    def instrument_tornado_ioloop():
-        # type: () -> None
-        ioloop._poll = InstrumentedPoll  # type: ignore # cross-version type variation is hard for mypy
-except Exception:
-    # Tornado 3
-    from tornado.ioloop import IOLoop, PollIOLoop
-    # There isn't a good way to get at what the underlying poll implementation
-    # will be without actually constructing an IOLoop, so we just assume it will
-    # be epoll.
-    orig_poll_impl = select.epoll
+class InstrumentedPollIOLoop(PollIOLoop):
+    def initialize(self, **kwargs):  # type: ignore # TODO investigate likely buggy monkey patching here
+        super(InstrumentedPollIOLoop, self).initialize(impl=InstrumentedPoll(), **kwargs)
 
-    class InstrumentedPollIOLoop(PollIOLoop):
-        def initialize(self, **kwargs):  # type: ignore # TODO investigate likely buggy monkey patching here
-            super(InstrumentedPollIOLoop, self).initialize(impl=InstrumentedPoll(), **kwargs)
-
-    def instrument_tornado_ioloop():
-        # type: () -> None
-        IOLoop.configure(InstrumentedPollIOLoop)
+def instrument_tornado_ioloop():
+    # type: () -> None
+    IOLoop.configure(InstrumentedPollIOLoop)
 
 # A hack to keep track of how much time we spend working, versus sleeping in
 # the event loop.
diff --git a/zproject/jinja2/__init__.py b/zproject/jinja2/__init__.py
index 462837a799..9ace126ac4 100644
--- a/zproject/jinja2/__init__.py
+++ b/zproject/jinja2/__init__.py
@@ -24,7 +24,7 @@ def environment(**options):
         'minified_js': minified_js,
     })
 
-    env.install_gettext_translations(translation, True)  # type: ignore # https://github.com/python/typeshed/issues/927
+    env.install_gettext_translations(translation, True)
 
     env.filters['slugify'] = slugify
     env.filters['pluralize'] = pluralize